ScalaireV1, Main, Exploration, bibRecord, 000244

Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

Identifieur interne : 000244 ( Main/Exploration ); précédent : 000243; suivant : 000245

Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

Auteurs : William W. Yuen [États-Unis] ; Nan R. Du [États-Unis] ; Chun H. Chan [États-Unis] ; Eduardo A. Silva [États-Unis] ; David J. Mooney [États-Unis]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2010.

RBID : PMC:2964247

Abstract

Nature frequently utilizes opposing factors to create a stable activator gradient to robustly control pattern formation. This study employs a biomimicry approach, by delivery of both angiogenic and antiangiogenic factors from spatially restricted zones of a synthetic polymer to achieve temporally stable and spatially restricted angiogenic zones in vivo. The simultaneous release of the two spatially separated agents leads to a spatially sharp angiogenic region that is sustained over 3 wk. Further, the contradictory action of the two agents leads to a stable level of proangiogenic stimulation in this region, in spite of significant variations in the individual release rates over time. The resulting spatially restrictive and temporally sustained profiles of active signaling allow the creation of a spatially heterogeneous and functional vasculature.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964247

DOI: 10.1073/pnas.1001192107
PubMed: 20921366
PubMed Central: 2964247

Affiliations:

Le document en format XML

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Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

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